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(PubMed) Khajehdehi P, Pakfetrat M, Javidnia K, et al

In mouse cervical tumors, lactate dehydrogenase A (LDHA), as an enzyme involved in energy metabolism, is abnormally translocated to the cell nucleus due to the increase of intracellular ROS caused by HPV-16 E7

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Jiang DQ, et al

Conversely, other studies have demonstrated that lactic acid may partially restore PGC-1 activity, reduce the expression of pro-inflammatory cytokines including TNF-, IL-1, and IL-6, alleviate renal injury, and improve survival in murine models of sepsis-induced AKI (Takakura and Zandi-Nejad, 2019)